培养的大鼠垂体前叶细胞中的雄激素代谢
Androgen metabolism in rat anterior pituitary cells in culture.
作者信息
Belanger A, Lundell L, Eneroth P, Gustafsson J A
出版信息
Mol Cell Endocrinol. 1980 Aug;19(2):175-81. doi: 10.1016/0303-7207(80)90020-9.
The metabolism in vitro of 4 androgens, namely testosterone, androstenedione, 5 alpha-dihydrotestosterone and 3 alpha-androstanediol has been studied in male and female rat anterior pituitary cells in primary culture. When testosterone was used as precursor, androstenedione, 5 alpha-dihydrotestosterone and 3 alpha-androstanediol were the main metabolites whereas androstendione was mainly converted into testosterone, 5 alpha-androstanedione, 5 alpha-dihydrotestosterone and androsterone. Studies on the metabolism of 5 alpha-dihydrotestosterone and 3 alpha-androstanediol showed that these compounds were easily interconverted and were also significantly metabolized to 5 alpha-androstanedione and androsterone. No aromatized compounds could be detected suggesting that androgen action in the pituitary cell occurs directly via the androgen receptor rather than through prior conversion into estrogens.
在原代培养的雄性和雌性大鼠垂体前叶细胞中，对4种雄激素，即睾酮、雄烯二酮、5α-双氢睾酮和3α-雄烷二醇的体外代谢进行了研究。当以睾酮作为前体时，雄烯二酮、5α-双氢睾酮和3α-雄烷二醇是主要代谢产物，而雄烯二酮主要转化为睾酮、5α-雄烷二酮、5α-双氢睾酮和雄酮。对5α-双氢睾酮和3α-雄烷二醇代谢的研究表明，这些化合物很容易相互转化，并且也显著代谢为5α-雄烷二酮和雄酮。未检测到芳香化化合物，这表明垂体细胞中的雄激素作用是直接通过雄激素受体发生的，而不是通过先转化为雌激素。
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