Lazăr C, Pop T, Dumitrache D, Mamulea O
Rev Chir Oncol Radiol O R L Oftalmol Stomatol Chir. 1978 Sep-Oct;27(5):379-85.
The carcino-embrionary antigen was estimated in 26 patients without malignant diseases (15 with inguinal hernia and 11 with urinary lithiasis--all of them before surgery), and in 47 patients with urothelial tumors. The direct radioimmune technique was used (a commercial kit from France /CEA IRE SORIN/) applied to isolated samples of sterile urine obtained at 12 hours. It was noted that:--patients without urologic disturbances had values under 1.5 micrograms in 12 hours in 93.4% of the cases;--in 44% of patients with non-malignant urological diseases (urinary lithiasis) the antigen values ranged between 1.5 and 3.0 micrograms in 12 hours;--patients with urothelial tumors had high values of the urinary carcinoembrionary antigen, in the range between 1.92 and 162.5 micrograms;--concentration of the urinary carcino-embionary antigen increases with the stage of the disease, with tumor polyploidia and in tumors with a high degree of anaplasia;--10--14 days after the removal of the tumor the values of the carcino-embrionary antigen show a significant decrease, even after total cystectomy but with cutaneous uretherostomy.
对26例无恶性疾病的患者（15例腹股沟疝患者和11例尿路结石患者——均在手术前）以及47例尿路上皮肿瘤患者的癌胚抗原进行了评估。采用直接放射免疫技术（使用法国的一种商用试剂盒/CEA IRE SORIN/），应用于12小时采集的无菌尿液分离样本。结果发现：——无泌尿系统疾病的患者93.4%在12小时内癌胚抗原值低于1.5微克；——44%患有非恶性泌尿系统疾病（尿路结石）的患者在12小时内抗原值在1.5至3.0微克之间；——尿路上皮肿瘤患者尿癌胚抗原值较高，在1.92至162.5微克之间；——尿癌胚抗原浓度随疾病分期、肿瘤多倍体情况以及间变程度高的肿瘤而增加；——肿瘤切除后10至14天，癌胚抗原值显著下降，即使在全膀胱切除并做皮肤输尿管造口术后也是如此。
