Gerber A, Frimodt-Möller N, Craig W A
Infection. 1980;8 Suppl 3:S 276-9. doi: 10.1007/BF01639594.
In vitro tissue binding of clindamycin, trimethoprim and rifampin to serial dilutions of canine tissue homogenates was studied. For all three drugs tested, the percentage of bound drug tended to be linearly related to the logarithm of the percentage of tissue homogenate. Tissue binding studies of antimicrobials looking at a single concentration or tissue homogenate may give erroneous results that do not reflect tissue binding in vivo.
研究了克林霉素、甲氧苄啶和利福平在体外与犬组织匀浆系列稀释液的组织结合情况。对于所测试的这三种药物，结合药物的百分比往往与组织匀浆百分比的对数呈线性关系。仅观察单一浓度或组织匀浆的抗菌药物组织结合研究可能会得出错误结果，无法反映体内的组织结合情况。
