山羊和一头奶牛组织中甲氧苄啶和磺胺多辛的浓度。
Concentrations of trimethoprim and sulphadoxine in tissues from goats and a cow.
作者信息
Nielsen P, Rasmussen F
出版信息
Acta Vet Scand. 1975;16(3):405-10. doi: 10.1186/BF03546658.
Abstract
The concentration of trimethoprim and sulphadoxine in plasma and tissue from goats and a cow have been determined after a single intravenous injection. Furthermore, the concentration of the two drugs and their metabolites in plasma and tissues have been determined after continuous intravenous infusion for 2½–3 hrs. Trimethoprim was present in all tissues but brain at higher concentrations than in plasma while the concentration of sulphadoxine in the different tissues were lower than in plasma. The highest concentration of the 2 drugs and their metabolites was found in the kidney. The distribution pattern of trimethoprim and sulphadoxine was similar in cow and goats.
摘要
单次静脉注射后，测定了山羊和一头奶牛血浆及组织中甲氧苄啶和磺胺多辛的浓度。此外，在持续静脉输注2.5 - 3小时后，测定了血浆和组织中这两种药物及其代谢物的浓度。除大脑外，所有组织中的甲氧苄啶浓度均高于血浆，而不同组织中磺胺多辛的浓度低于血浆。这两种药物及其代谢物在肾脏中的浓度最高。甲氧苄啶和磺胺多辛在奶牛和山羊体内的分布模式相似。
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