Souster L P, Emery J L
J Anat. 1980 May;130(Pt 3):595-602.
An attempt was made to obtain normal values of the sizes of glomeruli in the fetus and child. The kidneys of 117 children from 12 weeks gestation to 5 years of age were measured and the difference in size between the juxta-arcuate, mid-cortical and superficial glomeruli was examined. Juxta-arcuate and mid-cortical glomeruli showed an initial decrease in size from 12 to 20 weeks gestation. This was not seen in the most superficial glomeruli. After the initial decrease, the juxta-arcuate and superficial glomeruli remained at the same size until birth. The superficial glomeruli remained the same size from 12 weeks gestation to term. There was an immediate increase in size after birth in all three groups which slowed down after 2 years, when all three groups became the same size. The changes in size of the juxta-arcuate and mid-cortical glomeruli may be explained by functional demand.
研究人员试图获取胎儿和儿童肾小球大小的正常值。对117名从妊娠12周直至5岁儿童的肾脏进行了测量,并检测了近弓状、皮质中部和浅表肾小球之间的大小差异。近弓状和皮质中部肾小球在妊娠12至20周时大小出现了初步减小。最浅表的肾小球未出现这种情况。在初步减小之后,近弓状和浅表肾小球在出生前大小保持不变。浅表肾小球从妊娠12周直至足月大小保持不变。出生后所有三组肾小球大小立即增大,两年后增速放缓,此时三组肾小球大小相同。近弓状和皮质中部肾小球大小的变化可能由功能需求来解释。