Ferreira A, Michaelson J, Nussenzweig V
J Immunol. 1980 Sep;125(3):1178-82.
Three phenotypes of the gamma-chain of mouse C4 have been detected by a modification of the two-dimensional O'Farrell technique. Strains carrying the H-2s, H-2p, H-2f and H-2ja haplotypes had chains with pI 7.4 (gamma 1). Strains with H-2k, H-2q, H-2d, H-2r, H-2b, H-2u, and H-2w7 had gamma-chains with pI 6.9 (gamma 2), and strains carrying a wild-derived haplotype had gamma chains with pI 6.5 (gamma 3). The genes controlling this polymorphism were mapped in the S region of the H-2 complex by using congenic strains.
通过对二维O'Farrell技术进行改进，已检测到小鼠C4γ链的三种表型。携带H-2s、H-2p、H-2f和H-2ja单倍型的品系具有pI为7.4的链（γ1）。具有H-2k、H-2q、H-2d、H-2r、H-2b、H-2u和H-2w7的品系具有pI为6.9的γ链（γ2），而携带野生衍生单倍型的品系具有pI为6.5的γ链（γ3）。通过使用同类系，将控制这种多态性的基因定位在H-2复合体的S区域。
