Parker K L, Carroll M C, Shreffler D C, Capra J D
J Immunol. 1981 Mar;126(3):995-7.
H-2 haplotype-related structural variation in Slp beta-chains was detected by the limited proteolysis peptide mapping technique. Two distinct peptide patterns were distinguished: Slp.1 was found in strains carrying the S regions of the H-2d and H-2s haplotypes, and Slp.2 was found in strains bearing the S region of H-2w7. These different patterns were expressed codominantly in male (Sd X Sw7)F1 hybrids, whereas only the Slp.2 pattern was expressed in female heterozygotes. The 2 beta-chains are most likely the products of alleles of the Slp structural gene, which must then be located in the murine major histocompatibility complex, very probably in the S region.
通过有限蛋白酶解肽图谱技术检测到Slpβ链中与H-2单倍型相关的结构变异。区分出两种不同的肽图谱：在携带H-2d和H-2s单倍型S区域的品系中发现了Slp.1，在携带H-2w7 S区域的品系中发现了Slp.2。这些不同的图谱在雄性（Sd×Sw7）F1杂种中呈共显性表达，而在雌性杂合子中仅表达Slp.2图谱。这两条β链很可能是Slp结构基因等位基因的产物，该基因必定位于小鼠主要组织相容性复合体中，极有可能在S区域。
