Russell J H, Dobos C B
J Immunol. 1980 Sep;125(3):1256-61.
Within minutes of CTL-target interaction, the intracellular disintegration of the target cell nucleus begins. This nuclear event satisfies the ionic and temperature requirements that have been described by others as important in CTL-mediated lysis. Such nuclear disintegration does not occur in Ab+C-lysed targets. Thus the target cell nucleus appears to signal a primary event in CTL-mediated lysis that distinguishes the CTL lytic mechanism from that of Ab+C.
在细胞毒性T淋巴细胞（CTL）与靶细胞相互作用的几分钟内，靶细胞核的细胞内解体就开始了。这种核事件满足了其他人所描述的在CTL介导的裂解中很重要的离子和温度要求。这种核解体在抗体加补体（Ab + C）裂解的靶细胞中不会发生。因此，靶细胞核似乎标志着CTL介导的裂解中的一个主要事件，这将CTL的裂解机制与Ab + C的裂解机制区分开来。
