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病毒特异性CD8 + 细胞毒性T淋巴细胞克隆在小鼠肝炎病毒感染细胞中诱导的细胞凋亡。

Apoptosis induced in mouse hepatitis virus-infected cells by a virus-specific CD8+ cytotoxic T-lymphocyte clone.

作者信息

Shibata S, Kyuwa S, Lee S K, Toyoda Y, Goto N

机构信息

Laboratory of Veterinary Pathology, Faculty of Agriculture, University of Tokyo, Japan.

出版信息

J Virol. 1994 Nov;68(11):7540-5. doi: 10.1128/JVI.68.11.7540-7545.1994.

DOI:10.1128/JVI.68.11.7540-7545.1994
PMID:7933139
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC237198/
Abstract

Morphological changes of mouse hepatitis virus-infected J774.1 cells cocultured with cloned mouse hepatitis virus-specific CD8+ cytotoxic T lymphocytes were examined by electron microscopy. Condensation and margination of chromatin, cellular shrinkage with severe vacuolar degeneration, and blebbing were observed. In addition, fragmentation of cellular DNA was observed, and a decrease in virus titer was accompanied by those changes. These findings show that the cloned cytotoxic T lymphocytes induce in the target cell an internal degradation program termed apoptosis, which results in virus clearance.

摘要

通过电子显微镜检查了与克隆的小鼠肝炎病毒特异性CD8 + 细胞毒性T淋巴细胞共培养的小鼠肝炎病毒感染的J774.1细胞的形态学变化。观察到染色质浓缩和边缘化、细胞皱缩并伴有严重的空泡变性以及细胞起泡。此外，还观察到细胞DNA片段化，并且病毒滴度的降低伴随着这些变化。这些发现表明，克隆的细胞毒性T淋巴细胞在靶细胞中诱导了一种称为凋亡的内部降解程序，这导致了病毒清除。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d2b/237198/b66e30ceffea/jvirol00020-0731-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d2b/237198/0c49ca4fba56/jvirol00020-0729-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d2b/237198/63d27a70a184/jvirol00020-0730-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d2b/237198/484ea21945b5/jvirol00020-0731-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d2b/237198/b66e30ceffea/jvirol00020-0731-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d2b/237198/0c49ca4fba56/jvirol00020-0729-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d2b/237198/63d27a70a184/jvirol00020-0730-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d2b/237198/484ea21945b5/jvirol00020-0731-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d2b/237198/b66e30ceffea/jvirol00020-0731-b.jpg

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Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.细胞毒性淋巴细胞在同种异体靶细胞中快速诱导DNA片段化和凋亡需要颗粒酶B。
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