钠/钙转运对静息膜电位的作用。
Contribution of Na/Ca transport to the resting membrane potential.
作者信息
Sjodin R A
出版信息
J Gen Physiol. 1980 Jul;76(1):99-108. doi: 10.1085/jgp.76.1.99.
Abstract
Relations are derived that describe the combined effects of electrodiffusion, the Na/K pump, and Na/Ca transport by carrier on the resting membrane potential. Equations are derived that apply to both steady-state and non-steady-state conditions. Some example calculations from the equations are plotted at different permeability coefficient ratios, PK:PCa:PNa. The equations predict a depolarizing action of Na/Ca transport when more than two Na ions per Ca ion are transported by the carrier. For all permeability ratios examined, a steady state for Ca ions is achieved with at most a few millivolts of depolarization.
摘要
推导了描述电扩散、钠钾泵以及载体介导的钠钙转运对静息膜电位综合作用的关系式。推导了适用于稳态和非稳态条件的方程。根据这些方程进行的一些示例计算，以不同的渗透系数比PK:PCa:PNa绘制而成。这些方程预测，当载体每转运一个钙离子就转运超过两个钠离子时，钠钙转运具有去极化作用。对于所研究的所有渗透比，钙离子可实现稳态，去极化幅度至多为几毫伏。
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