“恒场方程”在膜离子转运中的持久影响。
The enduring legacy of the "constant-field equation" in membrane ion transport.
机构信息
Departamento de Biología, Facultad de Ciencias, Santiago, Chile.
Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile
出版信息
J Gen Physiol. 2017 Oct 2;149(10):911-920. doi: 10.1085/jgp.201711839. Epub 2017 Sep 20.
In 1943, David Goldman published a seminal paper in that reported a concise expression for the membrane current as a function of ion concentrations and voltage. This body of work was, and still is, the theoretical pillar used to interpret the relationship between a cell's membrane potential and its external and/or internal ionic composition. Here, we describe from an historical perspective the theory underlying the constant-field equation and its application to membrane ion transport.
1943 年，David Goldman 在 发表了一篇开创性的论文，其中报告了一个简洁的膜电流表达式，作为离子浓度和电压的函数。这部分工作是，并且仍然是，用于解释细胞的膜电位与其外部和/或内部离子组成之间关系的理论支柱。在这里，我们从历史的角度描述了恒定场方程的理论基础及其在膜离子转运中的应用。
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