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精子转谷氨酰胺酶的鉴定及其可能的生物学意义

Identification and possible biological relevance of spermatozoal transglutaminase.

作者信息

Ablin R J, Whyard T C

机构信息

Department of Urology, State University of New York, Stony Brook 11794-8093.

出版信息

Experientia. 1991 Mar 15;47(3):277-9. doi: 10.1007/BF01958159.

DOI:10.1007/BF01958159
PMID:1672655
Abstract

Normal human spermatozoa were demonstrated by dot immunoblot analysis and immunohistochemistry to possess transglutaminase (TGase). The immunological identification of spermatozoal TGase is consistent with reports by others of its biochemical identification and suggested role in sperm motility, and provides, in view of the immunoregulatory properties of seminal plasma TGase, presumptive identification of a means whereby spermatozoa, under normal physiological conditions, may possibly be protected from immunological 'attack' within the female reproductive tract.

摘要

通过斑点免疫印迹分析和免疫组织化学证明,正常人精子含有转谷氨酰胺酶(TGase)。精子TGase的免疫学鉴定与其他人关于其生化鉴定及其在精子运动中作用的报道一致,并且鉴于精浆TGase的免疫调节特性,推测鉴定出一种在正常生理条件下精子可能免受女性生殖道内免疫“攻击”的方式。

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Identification and possible biological relevance of spermatozoal transglutaminase.精子转谷氨酰胺酶的鉴定及其可能的生物学意义
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引用本文的文献

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Prostate transglutaminase (TGase-4) antagonizes the anti-tumour action of MDA-7/IL-24 in prostate cancer.前列腺转谷氨酰胺酶 (TGase-4) 拮抗 MDA-7/IL-24 在前列腺癌中的抗肿瘤作用。
J Transl Med. 2011 Apr 28;9:49. doi: 10.1186/1479-5876-9-49.

本文引用的文献

1
Effect of human seminal plasma on tumour-associated immunity in patients with adenocarcinoma of the prostate.人精浆对前列腺腺癌患者肿瘤相关免疫的影响。
J Reprod Immunol. 1980 Feb;1(5-6):337-45. doi: 10.1016/0165-0378(80)90007-8.
2
Interaction between tissue transglutaminase and phospholipid vesicles.组织转谷氨酰胺酶与磷脂囊泡之间的相互作用。
FEBS Lett. 1983 May 2;155(1):1-5. doi: 10.1016/0014-5793(83)80196-3.
3
Transglutaminases.转谷氨酰胺酶
Annu Rev Biochem. 1980;49:517-31. doi: 10.1146/annurev.bi.49.070180.002505.