Leyson J F, Martin B F, Sporer A
J Urol. 1980 Jul;124(1):82-4. doi: 10.1016/s0022-5347(17)55307-0.
The pharmacodynamics of baclofen on the bladder and urethral sphincters in acute and chronic spinal cord injury male patients were evaluated. A total of 100 supine and sitting urodynamic profiles was done in 25 patients. Baclofen decreased external urethral sphincter resistance by depressing pudendal-to-pudendal nerve reflex through spinal cord presynaptic hyperpolarization. This new centrally acting antispastic drug produced a significant reduction of residual urine in 73 per cent of the cases within an average of 4.98 weeks. Baclofen is a new alternative in the medical treatment of postural non-electrically induced detrusor striated sphincter dyssynergia in spinal cord injury patients. Indications for external sphincterotomy are discussed.
评估了巴氯芬对急性和慢性脊髓损伤男性患者膀胱和尿道括约肌的药效学。对25例患者进行了总共100次仰卧位和坐位尿动力学检查。巴氯芬通过脊髓突触前超极化抑制阴部神经到阴部神经反射，从而降低尿道外括约肌阻力。这种新型中枢性抗痉挛药物在平均4.98周内使73%的病例残余尿量显著减少。巴氯芬是脊髓损伤患者姿势性非电诱导逼尿肌-横纹肌括约肌协同失调药物治疗的新选择。讨论了外括约肌切开术的适应证。
