Zadionchenko V S, Kopalova S M
Kardiologiia. 1980 Aug;20(8):75-9.
The results of ergometric examination of 316 patients with chronic coronary insufficiency and various types of hyperlipoproteinemia have shown a clear diminution of physical working capacity in patients with hyperlipidemia as compared to patients with hyperlipidemia as compared to patients in whom the lipid content is within normal values. Working capacity was most diminished in IIa and particularly IIb types of hyperlipoproteinemia; in type IV physical working capacity was not reduced. The effect of hyperlipoproteinemia is most significant in the mildest degree of coronary insufficiency, but reduces or vanishes completely with increasing severity of the disease. An inverse relationship has been established between the value of physical working capacity and the level of cholesterol and beta-lipoproteins and a direct relationship in regard to NEFA concentration. Ergometry in patients with type II hyperlipoproteinemia showed that as compared to patients with normolipemia and type IV hyperlipoproteinemia an equal degree in the severity of the disease, the frequency and marked character of changes on the ECG increase; this evidences a more marked transitory myocardial ischemia.
对316例慢性冠状动脉供血不足及各种类型高脂蛋白血症患者进行的测力计检查结果显示，与血脂含量在正常范围内的患者相比，高脂血症患者的体力工作能力明显下降。在IIa型尤其是IIb型高脂蛋白血症中，工作能力下降最为明显；IV型患者的体力工作能力未降低。高脂蛋白血症的影响在冠状动脉供血不足最轻微的程度时最为显著，但随着疾病严重程度的增加而降低或完全消失。已确定体力工作能力值与胆固醇和β-脂蛋白水平呈反比关系，与游离脂肪酸浓度呈正比关系。对II型高脂蛋白血症患者进行的测力计检查表明，与血脂正常和IV型高脂蛋白血症患者相比，在疾病严重程度相同的情况下，心电图变化的频率和明显程度增加；这证明有更明显的短暂性心肌缺血。
