de Vega J C, Pais J R, del Tánago A G
Med Clin (Barc). 1980 May 25;74(10):387-94.
A total of 44 medical centers participated in a cooperative study on nosocomial infections. Percentages of Gram-negative, Gram-positive and anaerobic germs isolated during 30 alternate-days for 3 months were 80.35 percent, 17.25 percent and 0.52 percent, respectively. Activity of cefamandole and cefalotin against Gram-positive bacteria was very similar, and both antibiotics showed a low number of resistances. On the contrary, against Gram-negative strains the activity of cefamandole was definitely superior to that of cefalothin, but it was similar when compared to that of gentamicin. In many instances, cefamandole may be a valid alternative in treating hospital-acquired infections (except for Pseudomonas).
共有44个医疗中心参与了一项关于医院感染的合作研究。在3个月内每隔一天进行一次为期30天的采样，分离出的革兰氏阴性菌、革兰氏阳性菌和厌氧菌的百分比分别为80.35%、17.25%和0.52%。头孢孟多和头孢噻吩对革兰氏阳性菌的活性非常相似，两种抗生素的耐药菌株数量都很少。相反，对于革兰氏阴性菌株，头孢孟多的活性明显优于头孢噻吩，但与庆大霉素相比则相似。在许多情况下，头孢孟多可能是治疗医院获得性感染（除假单胞菌外）的有效替代药物。
