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恶性非霍奇金淋巴瘤肝脏病变的病理学(作者译)

[Pathology of liver lesions in malignant non-Hodgkin lymphomas (author's transl)].

作者信息

Grouls V, Stiens R

出版信息

Leber Magen Darm. 1980 Apr;10(2):83-90.

PMID:7412463
Abstract

The Kiel classification of lymphomas based on cytological criteria can be applied to tumor cell types found in liver infiltrates as well. Lymphomas with low degree of malignancy are delineated distinctly against the normal parenchyma; the borderline is slightly blurred only in the centroblastic-centrocytic subtype. Generally, the portal fields in these cases are round-shaped, expanded, and filled with lymphoid cells. Lymphomas with a high degree of malignancy are characterized on the contrary by portal fields with very irregular borderlines; in some cases there is a certain similarity to piece meal necrosis. There is an increased incidence of mitoses in the malignant tissue. Bile ducts are often disrupted. Hair cell leukemia can be differentiated in paraffin sections too, if tartrate-resistent acid phosphotase is present.

摘要

基于细胞学标准的淋巴瘤 Kiel 分类也可应用于肝浸润中发现的肿瘤细胞类型。恶性程度低的淋巴瘤与正常实质界限分明;仅在中心母细胞 - 中心细胞亚型中界限稍有模糊。一般来说,这些病例中的门管区呈圆形、扩大并充满淋巴细胞。相反,恶性程度高的淋巴瘤的特征是门管区边界非常不规则;在某些情况下,与碎片状坏死有一定相似性。恶性组织中有丝分裂发生率增加。胆管常被破坏。如果存在抗酒石酸酸性磷酸酶,毛细胞白血病在石蜡切片中也可鉴别。

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