Helber A, Wambach G, Böttcher W, Weller P, Schmidt R
Nephron. 1980;26(3):111-5. doi: 10.1159/000181964.
Patients with analgesic nephropathy are reported to have a higher risk of atherosclerosis. One possible reason for this is a high incidence of hyperlipaemia in patients with analgesic nephropathy. In a retrospective study, serum cholesterol and serum triglyceride concentrations of patients with analgesic nephropathy and moderately restricted renal function were significantly higher compared to a control group with other renal diseases of similar age and degree of renal insufficiency. Hyperlipaemia in analgesic nephropathy is not explained by end-stage renal failure on one side or protein loss as in nephrotic syndrome on the other side. Some possible mechanisms for hyperlipaemia in analgesic nephropathy are discussed.
据报道，镇痛剂肾病患者患动脉粥样硬化的风险更高。造成这种情况的一个可能原因是镇痛剂肾病患者高脂血症的发病率较高。在一项回顾性研究中，与年龄和肾功能不全程度相似的其他肾脏疾病对照组相比，镇痛剂肾病且肾功能中度受限患者的血清胆固醇和血清甘油三酯浓度显著更高。镇痛剂肾病中的高脂血症既不能用终末期肾衰竭来解释，也不能用肾病综合征中的蛋白质丢失来解释。本文讨论了镇痛剂肾病中高脂血症的一些可能机制。
