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周围神经系统髓鞘再生过程中的重塑

Remodelling during remyelination in the peripheral nervous system.

作者信息

Bonnaud-Toulze E N, Raine C S

出版信息

Neuropathol Appl Neurobiol. 1980 Jul-Aug;6(4):279-90. doi: 10.1111/j.1365-2990.1980.tb00212.x.

DOI:10.1111/j.1365-2990.1980.tb00212.x
PMID:7413013
Abstract

Morphologic analysis of longitudinal sections of lumbar anterior root tissue from rabbits at different stages of chronic experimental allergic encephalomyelitis has revealed new information on Schwann cell behaviour during early remyelination. Some short remyelinated internodes were displaced laterally towards nodes as other internodes elongated in a stepise fashion to occupy the vacated axonal segments. This suggests that a Schwann cell possesses the ability to remodel its myelin sheath after the initial establishment of the internode. Subaxolemmal densification was found to be formed wherever pairs of Schwann cells overlapped and gap junctions were observed between young Schwann cells.

摘要

对处于慢性实验性变应性脑脊髓炎不同阶段的家兔腰前根组织纵切片进行形态学分析,揭示了早期髓鞘再生过程中施万细胞行为的新信息。一些短的再生髓鞘节段向郎飞结侧向移位,而其他节段则呈阶梯状延长,以占据空出的轴突段。这表明施万细胞在节段最初形成后具有重塑其髓鞘的能力。发现在成对施万细胞重叠的任何部位均形成轴膜下致密化,并且在年轻施万细胞之间观察到缝隙连接。

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J Neurosci. 1996 Aug 15;16(16):4914-22. doi: 10.1523/JNEUROSCI.16-16-04914.1996.
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Quantitation of the Schmidt-Lanterman incisures in juvenile, adult, remyelinated and regenerated fibres of the chicken sciatic nerve.
鸡坐骨神经幼年期、成年期、再髓鞘化和再生纤维中施密特-兰特尔曼切迹的定量分析。
Acta Neuropathol. 1984;64(3):251-8. doi: 10.1007/BF00688116.
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Uncompacted myelin lamellae in two cases of peripheral neuropathy.
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Axon classes and internodal growth in the ventral spinal root L7 of adult and developing cats.成年和发育中猫的L7腹侧脊髓神经根中的轴突类别和结间生长
J Anat. 1988 Feb;156:71-96.
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Proliferation of Schwann cells in demyelinated rat sciatic nerve.
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