Chaudhuri M, Squibb R L, Solotorovsky M
Poult Sci. 1980 Aug;59(8):1736-41. doi: 10.3382/ps.0591736.
The chick was used as a rapid metabolic model to determine the fate of ingested fructose vs. glucose in noninfected chicks and in those subjected to the stress of avian tuberculosis. The chicks were crop-loaded with either a 72% fructose or glucose solution 21 and 28 days post TB inoculation and killed 2 and 4 hr after loading. In noninfected chicks, both sugars were rapidly converted to glycogen, and there was an interaction with time and the amount of glycogen formed from each sugar. Infection depressed glycogen formation from both fructose and glucose. While the total amount of glycogen formed from glucose could be directly correlated to increased liver size in the TB chicks loaded with glucose, in the chicks loaded with fructose less glycogen was formed even though liver size was increased as a result of the TB infection. The depression in glycogen formation was not related to the severity of the infection since the TB involvement was not the same in the two experiments conducted; but in both cases chicks loaded with fructose showed a greater reduction in the capacity of the liver to synthesize glycogen.
将雏鸡作为快速代谢模型，以确定未感染雏鸡以及遭受禽结核病应激的雏鸡摄入果糖与葡萄糖后的代谢去向。在接种结核病疫苗后第21天和第28天，给雏鸡嗉囊灌入72%的果糖溶液或葡萄糖溶液，灌胃后2小时和4小时将雏鸡处死。在未感染的雏鸡中，两种糖都迅速转化为糖原，并且时间与每种糖形成的糖原量之间存在相互作用。感染会抑制果糖和葡萄糖形成糖原。虽然在灌入葡萄糖的结核病雏鸡中，由葡萄糖形成的糖原总量与肝脏大小增加直接相关，但在灌入果糖的雏鸡中，尽管由于结核病感染肝脏大小增加，但形成的糖原较少。糖原形成的抑制与感染的严重程度无关，因为在进行的两个实验中结核病的累及情况不同；但在两种情况下，灌入果糖的雏鸡肝脏合成糖原的能力都有更大程度的降低。
