Carr L A, Wehry S M
Pharmacol Biochem Behav. 1980 Aug;13(2):193-7. doi: 10.1016/0091-3057(80)90072-6.
The ability of cycloheximide to inhibit brain catecholamine synthesis in C57BL/6J and DBA/2J mice was studied to determine whether differences exist in these two strains with regard to this action and whether such effects correlate with previously reported differences in sensitivity to the amnesic effects. Administration of cycloheximide caused a dose-dependent inhibition of norepinephrine and dopamine synthesis in both strains. There was a significant effect due to strain on dopamine synthesis in drug-treated animals. d-Amphetamine partially prevented the decrease in the rate of synthesis of norepinephrine, dopamine and normetanephrine caused by cycloheximide in the C57 strain but enhanced the inhibition of synthesis of these compounds in the DBA strain. The results suggest that the reported differences in sensitivity to the behavioral effects of cycloheximide may be associated with the degree of inhibition of catecholamine synthesis in these two mouse strains.
研究了环己酰亚胺抑制C57BL/6J和DBA/2J小鼠脑内儿茶酚胺合成的能力，以确定这两种品系在该作用方面是否存在差异，以及这种效应是否与先前报道的对遗忘效应敏感性的差异相关。给予环己酰亚胺会导致两种品系中去甲肾上腺素和多巴胺合成呈剂量依赖性抑制。在药物处理的动物中，品系对多巴胺合成有显著影响。右旋苯丙胺部分阻止了环己酰亚胺引起的C57品系中去甲肾上腺素、多巴胺和去甲变肾上腺素合成速率的下降，但增强了DBA品系中这些化合物合成的抑制作用。结果表明，报道的对环己酰亚胺行为效应敏感性的差异可能与这两种小鼠品系中儿茶酚胺合成的抑制程度有关。
