Kaul C L, Grewal R S
Pharmacology. 1980;21(3):223-8. doi: 10.1159/000137436.
An attempt has been made to measure changes in the endogenous noradrenaline contents of hearts and brains in rats made diabetic by intravenous administration of streptozotocin. There was no significant change in the endogenous noadrenaline content in the hearts and brains of these diabetic rats. However, all the diabetic animals showed increased excretion of adrenaline, noradrenaline and 3-methoxy-4-hydroxy mandelic acid. This increased excretion was seen as early as 3 days after streptozotocin injections. The rate of disappearance of (3H)-noradrenaline from the heart was significantly higher in these diabetic rats when compared to age-matched controls. It is concluded that there is an increased sympathetic activity in these diabetic animals which is reflected by increased disappearance of (3H)-noradrenaline and increased urinary catecholamine excretion.
已经尝试测量通过静脉注射链脲佐菌素诱导糖尿病的大鼠心脏和大脑中内源性去甲肾上腺素含量的变化。这些糖尿病大鼠的心脏和大脑中内源性去甲肾上腺素含量没有显著变化。然而，所有糖尿病动物的肾上腺素、去甲肾上腺素和3-甲氧基-4-羟基扁桃酸排泄量均增加。这种排泄增加早在注射链脲佐菌素后3天就出现了。与年龄匹配的对照组相比，这些糖尿病大鼠心脏中(3H)-去甲肾上腺素的消失速率显著更高。得出的结论是，这些糖尿病动物的交感神经活动增加，这表现为(3H)-去甲肾上腺素消失增加和尿儿茶酚胺排泄增加。
