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学习过程中杏仁核刺激对反常睡眠剥夺的逆转作用。

Reversal of paradoxical sleep deprivation by amygdaloid stimulation during learning.

作者信息

Smith C, Young J

出版信息

Physiol Behav. 1980 Jun;24(6):1035-9. doi: 10.1016/0031-9384(80)90043-8.

DOI:10.1016/0031-9384(80)90043-8
PMID:7413779
Abstract

Rats were subjected to a partial, selective paradoxical sleep (PS) deprivation. Two groups were trained in a shuttle avoidance task, one receiving posttraining amygdaloid stimulations (AS). A third group received AS, but was not trained. Levels of PS in the AS trained group were higher than in the AS non-trained controls, while the reverse was true for the slow wave sleep (SWS) measure. Both AS groups had levels of PS and SWS superior to the non-AS trained rats. In a second experiment, a group of normally rested AS animals was trained in the same task with a non-AS control group. These groups did not differ in terms of learning performance. Results were believed to support the hypothesis of a close relationship between sleep and learning.

摘要

对大鼠进行部分选择性异相睡眠(PS)剥夺。将两组大鼠训练穿梭箱回避任务,一组在训练后接受杏仁核刺激(AS)。第三组接受AS,但未进行训练。接受AS训练组的PS水平高于未接受AS训练的对照组,而慢波睡眠(SWS)测量结果则相反。两个接受AS组的PS和SWS水平均高于未接受AS训练的大鼠。在第二个实验中,一组正常休息的接受AS的动物与一个未接受AS的对照组一起训练同一任务。这些组在学习表现方面没有差异。结果被认为支持睡眠与学习之间密切关系的假设。

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引用本文的文献

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Activation of phasic pontine-wave generator prevents rapid eye movement sleep deprivation-induced learning impairment in the rat: a mechanism for sleep-dependent plasticity.激活相位性脑桥波发生器可预防大鼠快速眼动睡眠剥夺诱导的学习障碍:一种睡眠依赖性可塑性机制。
J Neurosci. 2004 Feb 11;24(6):1416-27. doi: 10.1523/JNEUROSCI.4111-03.2004.
2
Avoidance task training potentiates phasic pontine-wave density in the rat: A mechanism for sleep-dependent plasticity.回避任务训练增强大鼠的相位性脑桥波密度:一种睡眠依赖性可塑性机制。
J Neurosci. 2000 Nov 15;20(22):8607-13. doi: 10.1523/JNEUROSCI.20-22-08607.2000.