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测定人血小板中由花生四烯酸形成血栓素B2（TxB2）、12L-羟基-5,8,10-十七碳三烯酸（HHT）和12L-羟基-5,8,10,14-二十碳三烯酸（HETE）的情况，以及TxB2:HHT、TxB2:HETE和（TxB2 + HHT）:HETE的比值。探讨其在诊断方面的可能用途。

Determination of the formation of thromboxane B2 (TxB2), 12L-hydroxy-5,8,10 heptadecatrienoic acid (HHT) and 12L-hydroxy-5,8,10,14 eicosatrienoic acid (HETE) from arachidonic acid and of the TxB2 :HHT, TxB2 :HETE and (TxB2 +HHT) :HETE ratio in human platelets. Possible use in diagnostic purposes.

作者信息

Vincent J E, Zijlstra F J, van Vliet H

出版信息

Prostaglandins Med. 1980 Aug;5(2):79-84. doi: 10.1016/0161-4630(80)90094-4.

DOI:10.1016/0161-4630(80)90094-4
PMID:7413847
Abstract

The formation of thromboxane B2 (TxB2), 12L-hydroxy-5,8,10 heptadecatrienoic acid (HHT) and 12L-hydroxy-5,8,10,14 eicosatrienoic acid (HETE) was determined in the platelets of normal human males and of patients with disorders in which an abnormal platelet aggregation occurs. Platelets were labelled with [1-14C] arachidonic acid. After Aggregation and extraction the metabolites wee separated by TLC and determined. In the platelets of normal males, TxB2 values were in the range 4.4-12.4%, expressed as a percentage of total radioactivity. Curves were constructed for the following ratios: TxB2 :HHT, TxB2 :HETE and (TxB2 + HHT) :HETE. These ratios were fairly contant. A comparison was made with the ratios obtained in the platelets of a small number of patients with either an enhanced or a diminished aggregation.

摘要

在正常男性以及存在血小板异常聚集紊乱的患者血小板中，测定了血栓素B2（TxB2）、12L-羟基-5,8,10-十七碳三烯酸（HHT）和12L-羟基-5,8,10,14-二十碳三烯酸（HETE）的生成情况。血小板用[1-14C]花生四烯酸进行标记。聚集和提取后，代谢产物通过薄层层析法分离并测定。在正常男性血小板中，TxB2值占总放射性的百分比范围为4.4% - 12.4%。构建了以下比率的曲线：TxB2:HHT、TxB2:HETE以及（TxB2 + HHT）:HETE。这些比率相当恒定。将其与少数聚集增强或减弱患者血小板中获得的比率进行了比较。

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