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O,P'-滴滴涕对大鼠子宫胞质溶胶孕酮受体的雌激素样作用。

Estrogen-like effects of O,P'-DDT on the progesterone receptor of rat uterine cytosol.

作者信息

Mason R R, Schulte G J

出版信息

Res Commun Chem Pathol Pharmacol. 1980 Aug;29(2):281-90.

PMID:7414049
Abstract

Uterine cytosolic progesterone binding in ovariectromized mature rats, treated with 10mg o,p'-DDT, 1.0microgram estradiol or vehicle, was examined by a dextran-coated charcoal method and sucrose gradient density analysis. Increases in progesterone binding capacities in o,p'-DDT and estradiol treated groups were demonstrated. The characteristics of the progesterone binding component were comparable to those of progesterone receptors in rat uteri.

摘要

采用葡聚糖包被活性炭法和蔗糖梯度密度分析法,检测了用10mg邻,对'-滴滴涕、1.0微克雌二醇或赋形剂处理的去卵巢成熟大鼠子宫胞质孕酮结合情况。结果表明,邻,对'-滴滴涕和雌二醇处理组的孕酮结合能力增加。孕酮结合成分的特性与大鼠子宫中的孕酮受体相当。

相似文献

1
Estrogen-like effects of O,P'-DDT on the progesterone receptor of rat uterine cytosol.O,P'-滴滴涕对大鼠子宫胞质溶胶孕酮受体的雌激素样作用。
Res Commun Chem Pathol Pharmacol. 1980 Aug;29(2):281-90.
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Interaction of o,p'-DDT with the estrogen-binding protein (EBP) of DMBA-induced rat mammary tumors.
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Endocrinology. 1982 Nov;111(5):1498-504. doi: 10.1210/endo-111-5-1498.
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J Toxicol Environ Health. 1985;16(3-4):493-508. doi: 10.1080/15287398509530758.
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Studies on the estrogenic activity of chlordecone (Kepone) in the rat: effects on uterine estrogen receptor.开蓬(十氯酮)对大鼠雌激素活性的研究:对子宫雌激素受体的影响
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1-(o-Chlorophenyl)-1 (p-chlorophenyl)2,2,2-trichloroethane induces functional progestin receptors in the rat hypothalamus and pituitary gland.1-(邻氯苯基)-1-(对氯苯基)-2,2,2-三氯乙烷诱导大鼠下丘脑和垂体中的功能性孕激素受体。
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J Physiol Pharmacol. 2007 Dec;58(4):873-85.

引用本文的文献

1
In ovo exposure to o,p -DDE affects sexual development but not sexual differentiation in Japanese medaka (Oryzias latipes).在日本青鳉(Oryzias latipes)中,卵内暴露于邻,对 -滴滴涕会影响其性发育,但不会影响性分化。
Environ Health Perspect. 2003 Jan;111(1):29-32. doi: 10.1289/ehp.5540.