结直肠癌和腺瘤中的人类白细胞抗原（HLA）

HLA antigens in colorectal cancers and adenomas.

作者信息

Hiwatashi N, Kikuchi T, Masamune O, Ouchi E, Watanabe H, Goto Y

出版信息

Tohoku J Exp Med. 1980 Jul;131(3):257-60. doi: 10.1620/tjem.131.257.

DOI:10.1620/tjem.131.257

Abstract

An investigation was made of the differences between colorectal cancer and adenoma using HLA markers. Subjects included 60 cases of colorectal cancer, 43 of colorectal adenoma and 120 healthy Japanese controls. In comparison with the controls, Bw40 was increased (p < 0.02) and B5 was decreased (p < 0.005) in the colorectal adenoma cases, whereas in the colorectal cancer cases, Bw35 was increased (p < 0.005). B5 was significantly less frequent in the adenoma cases than in the cancer cases (p < 0.05). It is suggested that the susceptibility of BW35 to the causal factors of colorectal cancer is under genetic control.

摘要

利用人类白细胞抗原（HLA）标记物对结直肠癌与腺瘤之间的差异进行了一项研究。研究对象包括60例结直肠癌患者、43例结直肠腺瘤患者以及120名健康的日本对照者。与对照组相比，结直肠腺瘤患者中Bw40增加（p < 0.02），B5减少（p < 0.005）；而在结直肠癌患者中，Bw35增加（p < 0.005）。腺瘤患者中B5的出现频率显著低于癌症患者（p < 0.05）。提示BW35对结直肠癌致病因素的易感性受遗传控制。