Mikuni I
Tokai J Exp Clin Med. 1980 Apr;5(2):243-50.
The similarity between vincristine sulfate-induced experimental cataract and posterior subcapsular cortical cataract in man is the grossly visible pathological processes of cataracts in the posterior subcapsular cortical region. In histological observations, these processes are described as degeneration and necrosis of the crystalline lens fibers immediately below the anterior capsular epithelial cells, as well as degeneration and necrosis of the cellular nuclei and irregularity of the cellular arrangement in the bow area, and degeneration and vesicle formation of the lens fibers immediately below the posterior capsule. The dissimilarities, on the other hand, are as follows: the posterior subcapsular cortical cataract in man, compared with vincristine salfate-induced cataract, is characterized by less advanced degeneration and atrophy of the anterior capsular epithelial cells and lack of specific changes of their nuclei. In man, cellular stratification was also lacking in the bow area.
硫酸长春新碱诱导的实验性白内障与人后囊下皮质性白内障之间的相似之处在于后囊下皮质区域白内障明显可见的病理过程。在组织学观察中，这些过程被描述为前囊上皮细胞下方晶状体纤维的变性和坏死，以及弓状区细胞核的变性和坏死、细胞排列不规则，还有后囊下方晶状体纤维的变性和小泡形成。另一方面，不同之处如下：与人后囊下皮质性白内障相比，硫酸长春新碱诱导的白内障的特征是前囊上皮细胞的变性和萎缩程度较轻，且其细胞核缺乏特异性变化。在人类中，弓状区也缺乏细胞分层现象。
