El-Aaser A A, El-Merzabani M M, El-Bolkainy M N, Ibrahim A S, Zakhary N I, El-Morsi B
Tumori. 1980 Aug 31;66(4):409-14. doi: 10.1177/030089168006600401.
Urinary nitrite was present in 5.6% of 2379 individuals from a rural population infested with "Schistosoma haematobium". A higher frequency was observed in symptomatic patients with active bilharzial cystitis (25%) and patients with bladder cancer associated with schistosomiasis (66.2%); conversely, urinary nitrite was absent in normal urban individuals. The frequency of urinary nitrite was higher in females (6.4%) than males (4.6%), and was more frequent in adults than extremes of age. The presence of urinary nitrite was associated with urinary infection and was commonly accompanied by cellular atypia in urine, in the form of dysplasia. Under these circumstances, carcinogenic nitrosamines are liable to be produced in the bladder from urinary nitrite and amines. These observation support the possible role of urinary bacterial infection, commonly associated with bilharzial cystitis, in bladder carcinogenesis.
在感染“埃及血吸虫”的2379名农村人口中，5.6%的人尿中亚硝酸盐呈阳性。在患有活动性血吸虫膀胱炎的有症状患者中（25%）以及与血吸虫病相关的膀胱癌患者中（66.2%）观察到更高的频率；相反，正常城市个体的尿中亚硝酸盐呈阴性。女性尿中亚硝酸盐的频率（6.4%）高于男性（4.6%），且在成年人中比在年龄两端的人群中更常见。尿中亚硝酸盐的存在与泌尿系统感染相关，并且通常伴有尿液中的细胞异型性，表现为发育异常。在这种情况下，膀胱中可能会由尿中亚硝酸盐和胺类产生致癌性亚硝胺。这些观察结果支持了通常与血吸虫膀胱炎相关的泌尿系统细菌感染在膀胱癌发生中的可能作用。
