Dutertre Catella H, Phu Lich N, Quoc Quan D, Truhaut R
Toxicol Eur Res. 1978 Jul;1(4):209-16.
In the rabbit, isophorone alpha is partly eliminated, unchanged in the expired air and in the urine and, for another part, metabolized in the organism and excreted in the urine. The metabolites which have been characterized are : dimethyl-5,5, cyclohexen-1, one-3, carboxylic-1 acid, deriving from isophorone by methyloxidation, isophorol (trimethyl-3,5,5 cyclohexen-2, ol-1) formed by the reduction of the ketonic group into a secondary alcohol and eliminated as a glucuronide, dihydroisophorone (trimethyl-3,5,5, cyclohexanone) proceeding from the hydrogenation of the cyclohexen cycle and cis and trans trimethyl-3,5,5, cyclohexanols-1. These latter compounds, found in small quantities, are very likely issued from dihydroisophorone which is transformed in the organism into isophorone alpha and cis and trans trimethyl-3,5,5, cyclohexanols-1, according to a process of dismutation.
在兔体内，异佛尔酮α部分被消除，一部分以原形经呼气和尿液排出，另一部分则在体内代谢并经尿液排出。已鉴定出的代谢产物有：由异佛尔酮经甲基氧化生成的5,5 - 二甲基 - 环己烯 - 1 - 酮 - 3 - 羧酸；通过酮基还原为仲醇形成的异佛尔醇（3,5,5 - 三甲基 - 环己烯 - 2 - 醇 - 1），并以葡糖醛酸苷形式排出；由环己烯环氢化生成的二氢异佛尔酮（3,5,5 - 三甲基 - 环己酮）以及顺式和反式3,5,5 - 三甲基 - 环己醇 - 1。后几种化合物含量较少，很可能是由二氢异佛尔酮在体内通过歧化反应转化为异佛尔酮α以及顺式和反式3,5,5 - 三甲基 - 环己醇 - 1而产生的。
