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[广泛肺切除术中肺循环分流解剖生理基础的实验研究]

[Experimental study of the anatomical-physiological basis for pulmonary circulation shunting in extensive lung resections].

作者信息

Vaĭda R I

出版信息

Vestn Khir Im I I Grek. 1980 Jun;124(6):9-14.

PMID:7414871
Abstract

Bilateral extensive resections of lungs resulted in the development of stable pulmonary arterial hypertension, its degree correlating with the duration of the postoperative observation. Continuous hypertension in the pulmonary artery system is responsible for destructive changes in the intrapulmonary vessels and lung parenchyma promoting elevation of the vascular resistance in the small circuit and increased load to the right ventricle which further leads to decompensation of the cardio-pulmonary system. The author has shown that creation of extrapulmonary arterio-venous anastomosis in major lung resections can prevent the overloading of the right ventricle in the postoperative period, makes better conditions for compensatory changes in the remaining lung tissue without developing fibrosis.

摘要

双侧广泛性肺切除导致稳定型肺动脉高压的发生,其严重程度与术后观察的持续时间相关。肺动脉系统的持续性高血压会导致肺内血管和肺实质的破坏性改变,促使小循环血管阻力升高,右心室负荷增加,进而导致心肺系统失代偿。作者表明,在主要肺切除术中建立肺外动静脉吻合可以防止术后右心室过载,为剩余肺组织的代偿性改变创造更好的条件,且不会发生纤维化。

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