Nikulin A, Hegewald G, Gmaz-Nikulin E, Plamenac P, Bärenwald G
Zentralbl Allg Pathol. 1980;124(1-2):99-107.
An light and electronmicroscopic study of the rabbit hepatocytes during shock after experimental histamine release by Polymyxin-B-sulphate was made. As soon as five minutes after the histamine liberation the endoplasmatic reticulum becomes dissociated and the mitochondria show a spherical transformation. When the shock lasts up to one hour the changes are more intensive. The rest of deteriorated mitochondria and the endoplasmic membranes are expelled from the cells into the sinusoid lumina in form of myelinic figures. The hepatocyte microvilli swell up at first, and later, from the fifteenth minute after the beginning of shock they disappear which results in the flattening of the plasma membrane or its complete dissapearance in some places. Endothelial cells suffer similar alterations and they also acquire cytoplasmic protrusions. The findings lead to the conclusion that the changes of hepatocytes during shock after histamine liberation are primarily due to the direct influence of released histamine, and secondarily to the influence of hypoxia produced during the shock state.
对硫酸多粘菌素B诱导实验性组胺释放后休克状态下的家兔肝细胞进行了光镜和电镜研究。组胺释放后仅5分钟，内质网就开始解离，线粒体呈现球形转变。当休克持续1小时时，变化更为剧烈。其余变性的线粒体和内质网膜以髓鞘样结构的形式从细胞中被排出到肝血窦腔中。肝细胞微绒毛起初肿胀，随后，在休克开始后的第15分钟开始消失，这导致质膜变平或在某些部位完全消失。内皮细胞也发生类似改变，并出现细胞质突起。这些发现得出结论，组胺释放后休克期间肝细胞的变化主要是由于释放的组胺的直接影响，其次是休克状态下产生的缺氧的影响。
