Iakhin F A, Bazaz'ian G G, Sytina N P
Zh Nevropatol Psikhiatr Im S S Korsakova. 1980;80(6):871-6.
Case histories of 900 patients suffering from cerebrovascular diseases were analyzed. In 25 of them (2.8%) the disease got complicated with epileptic seizures. In 142 albino rats over 2 years of the age, both "sensitive" and "insensitive" to acoustic stimuli experimental atherosclerosis was induced by their long-time (for 3 to 5 months) keeping on Wilgram's atherogenic diet. As a result of the experiment it has been found that the atherogenic diet was conducive to development of hypercholesterolemia and depression of the blood anticoagulation system. As early as a month after the beginning of the diet application substantial shifts in the function of the central nervous system set in. These shifts were characterized by a shortening of the latent period of the reaction and the seizure and an intensification of the latter. The atherogenic diet led to development of audiogenic seizures in rats formerly insensitive to acoustic stimuli. Transfer of the animals to a cholesterol-free ration resulted in normalization of the blood anticoagulation system in 2 to 3 months. Within the same period the basic indices of the audiogenic reaction got normal, and the intensity of the epileptic seizures decreased.
对900例脑血管疾病患者的病历进行了分析。其中25例（2.8%）病情并发癫痫发作。对142只2岁以上的白化大鼠，通过长期（3至5个月）给予威尔格拉姆致动脉粥样化饮食，诱导出对听觉刺激“敏感”和“不敏感”的实验性动脉粥样硬化。实验结果发现，致动脉粥样化饮食有利于高胆固醇血症的发展和血液抗凝系统的抑制。早在开始应用该饮食一个月后，中枢神经系统功能就出现了显著变化。这些变化的特点是反应和癫痫发作的潜伏期缩短，且后者加剧。致动脉粥样化饮食导致以前对听觉刺激不敏感的大鼠出现听源性癫痫发作。将动物改为无胆固醇日粮后，血液抗凝系统在2至3个月内恢复正常。在同一时期，听源性反应的基本指标恢复正常，癫痫发作的强度降低。
