Molchanov V V, Karpel' G G, Panova L V, Serova T A
Zh Nevropatol Psikhiatr Im S S Korsakova. 1980;80(7):981-6.
Examinations of the clinical and immunological state of 68 patients with the acute stage of cerebral stroke were carried out, and so were immunomorphological examinations of the spleen and the subclavicular lymph nodes in 36 of them whose disease ended in death. An analysis of the results obtained has shown that the immunological reactivity increases from the very first day of the disease. The authors believe that the early immunological response, especially in cases of brain infarction, is due to development of the cerebral stroke in a sensitized body. A rise of selective antibody titres depending on the character of the cerebrovascular disorder was noted: there were: anti-encephalic antibodies targeted at the malacia focus in cases of brain infarction, and antivascular, and to a lesser extent anti-encephalic antibodies in cases of a hemorrhagic stroke. The informative value of the complement fixation test was found to be greater than that of the hemagglutination inhibition test. High degrees of plasmatization of the splenic tissue and the presence of the anti-encephalic immune complexes in it, mainly in cases of brain infarction, also point to the activity of the immunogenesis in the acute stage of the cerebral stroke.
对68例处于脑卒急性期患者的临床和免疫状态进行了检查，并对其中36例死亡患者的脾脏和锁骨下淋巴结进行了免疫形态学检查。对所得结果的分析表明，从疾病的第一天起免疫反应性就增强。作者认为，早期免疫反应，尤其是在脑梗死病例中，是由于脑卒中发生在致敏机体中。根据脑血管疾病的特征，观察到选择性抗体滴度升高：在脑梗死病例中，存在针对软化灶的抗脑抗体，而在出血性脑卒中病例中，存在抗血管抗体，以及程度较轻的抗脑抗体。发现补体结合试验的信息价值大于血凝抑制试验。脾脏组织的高度血浆化以及其中抗脑免疫复合物的存在，主要在脑梗死病例中，也表明脑卒急性期免疫发生的活性。
