Meyer I J, Thompson J A, Kiser E J, Haven G T
Am J Clin Pathol. 1980 Sep;74(3):332-6. doi: 10.1093/ajcp/74.3.332.
A variant creatine kinase (CK) isoenzyme was identified in the sera of some patients who had advanced adenocarcinoma of the breast, stomach, and large intestine. A similar variant isoenzyme, together with a high concentration of CK-BB isoenzyme, was identified in some breast tumor cytosols. The variant creatine kinase activity in both sera and tumor cytosols was unaffected by antibodies specific for both the CK-M and DK-B subunits. This indicates that DK-MB isoenzyme determinations are currently best performed by electrophoretic rather than immunologic technics.
在一些患有晚期乳腺癌、胃癌和大肠癌的患者血清中发现了一种变异肌酸激酶（CK）同工酶。在一些乳腺肿瘤细胞溶胶中也发现了类似的变异同工酶，以及高浓度的CK-BB同工酶。血清和肿瘤细胞溶胶中的变异肌酸激酶活性不受针对CK-M和CK-B亚基的特异性抗体的影响。这表明目前CK-MB同工酶的测定最好通过电泳技术而非免疫技术进行。
