Skatrud J, Iber C, McHugh W, Rasmussen H, Nichols D
Am Rev Respir Dis. 1980 Mar;121(3):587-93. doi: 10.1164/arrd.1980.121.3.587.
A 45-yr-old man with limb girdle muscular dystrophy, bilateral diaphragmatic paralysis, chronic carbon dioxide retention, and hypersomnolence was studied to determine the causes of hypoventilation during wakefulness and during sleep. Awake hypoventilation was associated with an insufficient inspiratory effort in the presence of inefficient respiratory muscles and a shortened inspiratory time. During sleep, severe hypoventilation and oxygen desaturation occurred only during REM-induced intercostal and accessory muscle inhibition.
一名45岁男性，患有肢带型肌营养不良、双侧膈肌麻痹、慢性二氧化碳潴留和嗜睡症，对其进行了研究以确定清醒和睡眠期间通气不足的原因。清醒时的通气不足与呼吸肌无力情况下吸气努力不足以及吸气时间缩短有关。在睡眠期间，严重的通气不足和氧饱和度下降仅发生在快速眼动（REM）诱导的肋间肌和辅助肌抑制期间。
