Estenne M, Yernault J C, De Troyer A
Am Rev Respir Dis. 1980 Jun;121(6):967-71. doi: 10.1164/arrd.1980.121.6.967.
We studied the effects of an intravenous injection of 5.0 mg of aminophylline per kg of body weight on lung mechanics in 8 normal subjects. No change occurred in lung volumes, airway resistance, and maximal expiratory flow-volume and lung pressure-volume curves. Restudy of 4 of the subjects before and after an injection of 8.0 mg/kg of aminophylline did not modify the pattern of response to the drug, despite a serum concentration range of 15.1 to 19.3 mg/l. These findings were, therefore, in contrast with those observed after the administration of atropine or beta-2 adrenergic derivatives. They suggested that the bronchodilator effects of aminophylline may not be due to a direct action of the drug on the bronchial smooth muscle.
我们研究了对8名正常受试者每千克体重静脉注射5.0毫克氨茶碱对肺力学的影响。肺容量、气道阻力、最大呼气流量-容积曲线和肺压力-容积曲线均未发生变化。对其中4名受试者在注射8.0毫克/千克氨茶碱前后进行重新研究，尽管血清浓度范围为15.1至19.3毫克/升，但对药物的反应模式并未改变。因此，这些发现与给予阿托品或β-2肾上腺素能衍生物后观察到的结果形成对比。它们表明氨茶碱的支气管扩张作用可能并非由于该药物对支气管平滑肌的直接作用。
