Restrepo A, Arango M D
Antimicrob Agents Chemother. 1980 Jul;18(1):190-4. doi: 10.1128/AAC.18.1.190.
A total of 60 clinical isolates of Paracoccidioides brasiliensis were tested for susceptibility to sulfadiazine and sulfadimethoxyne by the agar dilution technique. A modification of the Mueller-Hinton medium was devised which gave good growth of the yeast form. The minimum inhibitory concentrations for only 51.6% of the isolates were in the range of the recommended blood serum concentration (50 micrograms/ml). For 6 to 8% of the isolates, the minimum inhibitory concentrations were above 200 micrograms of both sulfadiazine and sulfadimethoxyne per ml. A significant decreases in susceptibility was demonstrated for one isolate obtained from a patient relapsing during sulfonamide therapy.
采用琼脂稀释法对总共60株巴西副球孢子菌临床分离株进行了磺胺嘧啶和磺胺二甲氧嘧啶敏感性测试。设计了一种改良的穆勒-欣顿培养基，该培养基能使酵母形态良好生长。仅51.6%的分离株的最低抑菌浓度在推荐血清浓度范围内（50微克/毫升）。对于6%至8%的分离株，磺胺嘧啶和磺胺二甲氧嘧啶的最低抑菌浓度均高于每毫升200微克。从一名在磺胺类药物治疗期间复发的患者身上获得的一株分离株显示出敏感性显著降低。
