甲氧苄啶与磺胺甲恶唑对巴西副球孢子菌的协同相互作用。
Synergistic interaction of trimethoprim and sulfamethoxazole on Paracoccidioides brasiliensis.
作者信息
Stevens D A, Vo P T
出版信息
Antimicrob Agents Chemother. 1982 May;21(5):852-4. doi: 10.1128/AAC.21.5.852.
Abstract
The in vitro interaction of trimethoprim and sulfamethoxazole on clinical isolates of Paracoccidioides brasiliensis was studied. With complete inhibition and a visual endpoint used as the criteria, three of four strains had minimal inhibitory concentrations that indicated resistance to sulfamethoxazole, and all four strains were resistant to trimethoprim. A marked synergism in inhibition was noted with the combination of these drugs against sulfa-resistant strains. A sulfamethoxazole/trimethoprim ratio of 5:1 was the most synergistic. Fifty percent inhibition, determined spectrophotometrically, of the strains could be achieved with sulfamethoxazole alone. In summary, the striking synergy observed suggests that combination chemotherapy with these drugs deserves further study.
摘要
研究了甲氧苄啶和磺胺甲恶唑对巴西副球孢子菌临床分离株的体外相互作用。以完全抑制和可视终点为标准，四株菌株中有三株的最低抑菌浓度表明对磺胺甲恶唑耐药，且所有四株菌株均对甲氧苄啶耐药。注意到这些药物联合使用对耐磺胺菌株具有显著的抑制协同作用。磺胺甲恶唑/甲氧苄啶比例为5:1时协同作用最强。仅用磺胺甲恶唑通过分光光度法测定可使菌株达到50%的抑制率。总之，观察到的显著协同作用表明，这些药物的联合化疗值得进一步研究。
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