• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Hypoxanthine-arabinoside pharmacokinetics after adenine arabinoside administration to a patient with renal failure.对一名肾衰竭患者给予阿糖腺苷后阿糖次黄嘌呤的药代动力学
Antimicrob Agents Chemother. 1980 Jul;18(1):212-4. doi: 10.1128/AAC.18.1.212.
2
Pharmacokinetics of vidarabine in the treatment of infants and children with infections due to herpesviruses.
J Infect Dis. 1983 Oct;148(4):721-5. doi: 10.1093/infdis/148.4.721.
3
Reversed-phase high-performance liquid chromatographic method to determine vidarabine and hypoxanthine arabinoside in biological fluids.反相高效液相色谱法测定生物流体中的阿糖腺苷和阿糖次黄嘌呤。
J Chromatogr. 1982 May 14;229(2):487-91. doi: 10.1016/s0378-4347(00)84296-6.
4
Metabolism and pharmacokinetics of the anti-varicella-zoster virus agent 6-dimethylaminopurine arabinoside.抗水痘-带状疱疹病毒药物6-二甲基氨基嘌呤阿拉伯糖苷的代谢与药代动力学
Antimicrob Agents Chemother. 1992 Feb;36(2):353-60. doi: 10.1128/AAC.36.2.353.
5
Pharmacokinetics of vidarabine in the treatment of polyarteritis nodosa.
Fundam Clin Pharmacol. 1992;6(1):11-5. doi: 10.1111/j.1472-8206.1992.tb00088.x.
6
Antiherpesvirus activity in human sera and urines after administration of adenine arabinoside: in vitro and in vivo synergy of adenine arabinoside and arabinosylhypoxanthine in combination.阿糖腺苷给药后人体血清和尿液中的抗疱疹病毒活性：阿糖腺苷与阿糖次黄嘌呤联合应用的体内外协同作用。
J Clin Invest. 1978 Dec;62(6):1142-53. doi: 10.1172/JCI109233.
7
Disseminated mucocutaneous herpes simplex type 2 infection in a renal transplant recipient: response to adenine arabinoside (Vidarabine).肾移植受者播散性皮肤黏膜单纯疱疹病毒2型感染：对阿糖腺苷（Vira-A）的反应
N Z Med J. 1980 Apr 9;91(657):252-3.
8
Herpes simplex encephalitis: treatment with adenine arabinoside and cytosine arabinoside.单纯疱疹性脑炎：用阿糖腺苷和阿糖胞苷治疗。
Med J Aust. 1978 Feb 25;1(4):181-3. doi: 10.5694/j.1326-5377.1978.tb107825.x.
9
Double blind trial in the treatment of herpes simplex and herpes zoster with adenine arabinoside and idoxuridine.阿糖腺苷和碘苷治疗单纯疱疹和带状疱疹的双盲试验。
Arch Dermatol Res. 1978 Jul 28;262(2):173-6. doi: 10.1007/BF00455387.
10
Clinical pharmacology of 9-beta-D-arabinofuranosyladenine in combination with 2'-deoxycoformycin.9-β-D-阿拉伯呋喃糖基腺嘌呤与2'-脱氧助间型霉素联合应用的临床药理学
Cancer Res. 1982 Sep;42(9):3884-6.

引用本文的文献

1
Comparative pharmacokinetics of antiviral nucleoside analogues.抗病毒核苷类似物的比较药代动力学
Clin Pharmacokinet. 1993 Feb;24(2):101-23. doi: 10.2165/00003088-199324020-00002.
2
Drug therapy in patients undergoing haemodialysis. Clinical pharmacokinetic considerations.接受血液透析患者的药物治疗。临床药代动力学考量
Clin Pharmacokinet. 1984 Jan-Feb;9(1):42-66. doi: 10.2165/00003088-198409010-00003.
3
Antiviral agents.抗病毒药物。
Med Clin North Am. 1988 May;72(3):691-715. doi: 10.1016/s0025-7125(16)30766-0.
4
Guide to drug dosage in renal failure.肾衰竭药物剂量指南。
Clin Pharmacokinet. 1988 Nov;15(5):326-54. doi: 10.2165/00003088-198815050-00005.
5
High-pressure liquid chromatographic methods for determining arabinosyladenine-5'-monophosphate, arabinosyladenine, and arabinosylhypoxanthine in plasma and urine.用于测定血浆和尿液中阿糖腺苷-5'-单磷酸、阿糖腺苷和阿糖次黄嘌呤的高压液相色谱法。
Antimicrob Agents Chemother. 1985 Aug;28(2):265-73. doi: 10.1128/AAC.28.2.265.

本文引用的文献

1
Linear pharmacokinetic equations allowing direct calculation of many needed pharmacokinetic parameters from the coefficients and exponents of polyexponential equations which have been fitted to the data.线性药代动力学方程允许根据已拟合数据的多指数方程的系数和指数直接计算许多所需的药代动力学参数。
J Pharmacokinet Biopharm. 1976 Oct;4(5):443-67. doi: 10.1007/BF01062831.
2
Antimicrobial dosage in renal failure: a unifying nomogram.肾衰竭时的抗菌药物剂量：统一列线图
Clin Nephrol. 1977 Feb;7(2):81-4.
3
Inappropriate antidiuretic hormone following adenine arabinoside administration.阿糖腺苷给药后出现抗利尿激素分泌异常综合征。
Antimicrob Agents Chemother. 1979 Jan;15(1):142-4. doi: 10.1128/AAC.15.1.142.
4
Adenine arabinoside therapy of biopsy-proved herpes simplex encephalitis. National Institute of Allergy and Infectious Diseases collaborative antiviral study.经活检证实的单纯疱疹性脑炎的阿糖腺苷治疗。国立过敏和传染病研究所协作抗病毒研究。
N Engl J Med. 1977 Aug 11;297(6):289-94. doi: 10.1056/NEJM197708112970601.

对一名肾衰竭患者给予阿糖腺苷后阿糖次黄嘌呤的药代动力学

Hypoxanthine-arabinoside pharmacokinetics after adenine arabinoside administration to a patient with renal failure.

作者信息

Aronoff G R, Szwed J J, Nelson R L, Marcus E L, Kleit S A

出版信息

Antimicrob Agents Chemother. 1980 Jul;18(1):212-4. doi: 10.1128/AAC.18.1.212.

DOI:10.1128/AAC.18.1.212
PMID:7416747
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC283968/
Abstract

Hypoxanthine arabinoside pharmacokinetics were measured during an adenine arabinoside continuous intravenous infusion and during hemodialysis in a patient with renal failure. Therapeutic guidelines for adenine arabinoside in renal failure are provided based on an elimination half-life of 4.7 h and a plasma clearance of 87.9 ml/min for the hypoxanthine metabolite.

摘要

在一名肾衰竭患者中，于阿糖腺苷持续静脉输注期间及血液透析期间测定了阿糖次黄嘌呤的药代动力学。基于阿糖次黄嘌呤代谢物4.7小时的消除半衰期和87.9毫升/分钟的血浆清除率，提供了肾衰竭患者使用阿糖腺苷的治疗指南。