对一名肾衰竭患者给予阿糖腺苷后阿糖次黄嘌呤的药代动力学
Hypoxanthine-arabinoside pharmacokinetics after adenine arabinoside administration to a patient with renal failure.
作者信息
Aronoff G R, Szwed J J, Nelson R L, Marcus E L, Kleit S A
出版信息
Antimicrob Agents Chemother. 1980 Jul;18(1):212-4. doi: 10.1128/AAC.18.1.212.
Abstract
Hypoxanthine arabinoside pharmacokinetics were measured during an adenine arabinoside continuous intravenous infusion and during hemodialysis in a patient with renal failure. Therapeutic guidelines for adenine arabinoside in renal failure are provided based on an elimination half-life of 4.7 h and a plasma clearance of 87.9 ml/min for the hypoxanthine metabolite.
摘要
在一名肾衰竭患者中，于阿糖腺苷持续静脉输注期间及血液透析期间测定了阿糖次黄嘌呤的药代动力学。基于阿糖次黄嘌呤代谢物4.7小时的消除半衰期和87.9毫升/分钟的血浆清除率，提供了肾衰竭患者使用阿糖腺苷的治疗指南。
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本文引用的文献
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2
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