[Suisaloral "Dessau"--a Salmonella cholerae suis live vaccine for oral, parenteral and combined applications].

An account is given of all immune preparations which had been available by summer 1976 and their uses in public disease control, with reference being made to the epizootiological role and detrimental effects of Salmonella cholerae suis (S. c.-s.). The need for using live Salmonella strains to test their immunogenic properties is derived from a thorough assessment of inactivated S.-c.-s.-vaccine, Salmoporc "Dessau", which had been used in the past. Salmonellae are pathogens of zoo-anthroponoses by their very nature, and the point is made that, therefore, comprehensive attention should be given to all aspects relating to genetic stability and identity of potential live vaccines. An S.-c.-s.-R-strain is described as the point of departure from which to develop a doubly attenuated strain, the basis of Salmonella cholerae suis live vaccine Suisaloral "Dessau". The live vaccine proper is characterised on the basis of results obtained from bacteriologico-serological, clinical, and epizootiological laboratory tests as well as preclinical and clinical tests applied to the animals (field testing). Suisaloral "Dessau" is the first Salmonella live vaccine on the basis of a non-reproduction-limited mutant with two independent genetic markers, and it is suitable for both oral and parenteral application. The vaccine also is widely applicable for combination with other live vaccines.