Schöll W, Grünert G
Arch Exp Veterinarmed. 1980;34(1):91-7.
An account is given of all immune preparations which had been available by summer 1976 and their uses in public disease control, with reference being made to the epizootiological role and detrimental effects of Salmonella cholerae suis (S. c.-s.). The need for using live Salmonella strains to test their immunogenic properties is derived from a thorough assessment of inactivated S.-c.-s.-vaccine, Salmoporc "Dessau", which had been used in the past. Salmonellae are pathogens of zoo-anthroponoses by their very nature, and the point is made that, therefore, comprehensive attention should be given to all aspects relating to genetic stability and identity of potential live vaccines. An S.-c.-s.-R-strain is described as the point of departure from which to develop a doubly attenuated strain, the basis of Salmonella cholerae suis live vaccine Suisaloral "Dessau". The live vaccine proper is characterised on the basis of results obtained from bacteriologico-serological, clinical, and epizootiological laboratory tests as well as preclinical and clinical tests applied to the animals (field testing). Suisaloral "Dessau" is the first Salmonella live vaccine on the basis of a non-reproduction-limited mutant with two independent genetic markers, and it is suitable for both oral and parenteral application. The vaccine also is widely applicable for combination with other live vaccines.
本文介绍了截至1976年夏季已有的所有免疫制剂及其在公共疾病控制中的应用，并提及猪霍乱沙门氏菌（S. c.-s.）的流行病学作用和有害影响。使用活沙门氏菌菌株来测试其免疫原性的必要性源于对过去使用过的灭活猪霍乱沙门氏菌疫苗Salmoporc “德绍” 的全面评估。沙门氏菌本质上是人畜共患病病原体，因此指出应全面关注与潜在活疫苗的遗传稳定性和一致性相关的所有方面。一种猪霍乱沙门氏菌R菌株被描述为开发双重减毒株的起点，双重减毒株是猪霍乱沙门氏菌活疫苗Suisaloral “德绍” 的基础。基于细菌学血清学、临床和流行病学实验室测试以及应用于动物的临床前和临床试验（现场测试）结果，对活疫苗本身进行了表征。Suisaloral “德绍” 是第一种基于具有两个独立遗传标记的非繁殖受限突变体的沙门氏菌活疫苗，适用于口服和非肠道给药。该疫苗也广泛适用于与其他活疫苗联合使用。
