Elizan T S, Terasaki P I, Yahr M D
Arch Neurol. 1980 Sep;37(9):542-4. doi: 10.1001/archneur.1980.00500580038004.
Eighteen unrelated American-Jewish patients of Eastern European extraction who had classical postencephalitic Parkinson's disease were typed for HLA-A, HLA-B, and HLA-C antigenic determinants. Compared with 147 ethnically matched controls, the HLA-B14 antigen showed a highly significantly increased frequency in the postencephalitic Parkinson's group (corrected P = .001). This association, though not necessarily reflecting genetic susceptibility to the disease, strongly suggests such a possibility in the pathogenesis of at least this particular variant of parkinsonism.
对18名具有东欧血统、患有典型脑炎后帕金森病的非亲属美国犹太患者进行了HLA - A、HLA - B和HLA - C抗原决定簇分型。与147名种族匹配的对照相比，脑炎后帕金森病组中HLA - B14抗原的频率显著升高（校正P = .001）。这种关联虽然不一定反映对该疾病的遗传易感性，但强烈提示至少在这种特定类型帕金森病的发病机制中存在这种可能性。
