Holmes D J, Miller W V, Rodey G E
Tissue Antigens. 1982 Mar;19(3):161-7. doi: 10.1111/j.1399-0039.1982.tb01435.x.
We describe a serum, 9045, that detects a subset of A28 bearing cells in a mixed population of American blacks, Caucasians of Jewish ancestry and non-Jewish Caucasians. The serum reacts preferentially with A28 positive cells from American Blacks and Jewish Caucasians and does not react with non-Jewish Caucasians. This new specificity, referred to as A28.2, is strongly associated with HLA-B14. In contrast, A28 positive but 9045 negative cells (referred to as A28.1) do not show this association. The A28-2 determinants appears to be antigenically similar to the A28.1 determinant, but distinct from the public antigenic determinants shared by A28, A2, A9 and by A28, Aw33, Aw34 and A26. Based upon this analysis, we conclude that HLA-A28, as defined by most A28 antisera, comprises at least two populations of molecules. The A28.2 form may have arisen in the Mediterranean basin region, whereas the A28.1 form seems to be more prevalent in non-Jewish Caucasians of Northern European ancestry.
我们描述了一种血清9045，它能在美洲黑人、犹太裔白种人和非犹太裔白种人的混合群体中检测出携带A28的细胞亚群。该血清优先与来自美洲黑人和犹太裔白种人的A28阳性细胞发生反应，而不与非犹太裔白种人反应。这种新的特异性被称为A28.2，它与HLA - B14密切相关。相比之下，A28阳性但9045阴性的细胞（称为A28.1）则不显示这种关联。A28 - 2决定簇在抗原性上似乎与A28.1决定簇相似，但与A28、A2、A9以及A28、Aw33、Aw34和A26共有的公共抗原决定簇不同。基于此分析，我们得出结论，大多数A28抗血清所定义的HLA - A28至少包含两个分子群体。A28.2形式可能起源于地中海盆地地区，而A28.1形式似乎在北欧血统的非犹太裔白种人中更为普遍。
