Lou H C
Arch Neurol. 1980 Sep;37(9):585-7. doi: 10.1001/archneur.1980.00500580081017.
Perinatal hypoxic-ischemic brain damage and intraventricular hemorrhage (IVH) are important causes of death and neurologic and intellectual dysfunction. Both lesions are related to perinatal asphyxia, and the aim of our review is to establish a comprehensive pathogenetic model. Our previous finding that cerebral blood flow is pressure-passive in perinatal distress is crucial, as periods of hypertension and hypotension alternate in the distressed infant. In hypertension, transmural pressure increases in the capillaries, leading to edema and, in premature infants, eventual rupture of vessels and IVH. Intraventricular hemorrhage induces vasospasm and ischemia. Ischemia is the direct result of hypotension. Cerebral blood flow studies performed a few hours after birth with subsequent examinations at one year of age point to a decisive effect of neonatal ischemia on subsequent development.
围产期缺氧缺血性脑损伤和脑室内出血（IVH）是死亡以及神经和智力功能障碍的重要原因。这两种损伤均与围产期窒息有关，我们综述的目的是建立一个全面的发病机制模型。我们之前的研究发现，围产期窘迫时脑血流呈压力被动状态，这一点至关重要，因为在窘迫婴儿中高血压和低血压时期交替出现。在高血压时，毛细血管跨壁压力增加，导致水肿，在早产儿中最终导致血管破裂和脑室内出血。脑室内出血会诱发血管痉挛和缺血。缺血是低血压的直接结果。出生后数小时进行的脑血流研究以及一岁时的后续检查表明，新生儿缺血对后续发育具有决定性影响。
