Kokron O, Pridun N, Zischinsky W
Wien Klin Wochenschr. 1978 Dec 22;90(24):864-7.
From 1975 to 1977 42 patients with advanced solid tumours were treated with imidazole-carboxamide (DTIC). It was applied in 18 cases as monotherapy: in the remaining patients it was administered in combination with other cytostatic agents. Tumour remission was recorded in 4/22 patients with melanoma, 2/2 with Kaposi sarcoma and 2/7 with soft tissue sarcoma. No change in tumour behaviour was recorded in 6/22 melanomas, 2/7 soft tissue sarcomas, 1/7 head and neck tumours and 1/1 thymoma. Side effects of DTIC monotherapy were comparably low. The optimum dosage and frequency of DTIC therapy have not yet been established. Combinations with other cytostatic agents are still being tested.
1975年至1977年，42例晚期实体瘤患者接受了咪唑甲酰胺（DTIC）治疗。18例患者采用单一疗法，其余患者则与其他细胞毒性药物联合使用。22例黑色素瘤患者中有4例出现肿瘤缓解，2例卡波西肉瘤患者中有2例出现缓解，7例软组织肉瘤患者中有2例出现缓解。22例黑色素瘤患者中有6例、7例软组织肉瘤患者中有2例、7例头颈部肿瘤患者中有1例、1例胸腺瘤患者中未观察到肿瘤行为变化。DTIC单一疗法的副作用相对较低。DTIC治疗的最佳剂量和频率尚未确定。与其他细胞毒性药物的联合应用仍在试验中。
