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大鼠中非多巴胺能中皮质和中边缘神经元的电生理证据。

Electrophysiological evidence for non-dopaminergic mesocortical and mesolimbic neurons in the rat.

作者信息

Thierry A M, Deniau J M, Herve D, Chevalier G

出版信息

Brain Res. 1980 Nov 10;201(1):210-4. doi: 10.1016/0006-8993(80)90788-x.

DOI:10.1016/0006-8993(80)90788-x
PMID:7417833
Abstract

The neurons located in the ventromedial tegmentum (VMT) and projecting either to the frontal cortex, to the septum or to the nucleus accumbens were identified by the antidromic activation method in normal rats and in animals whose dopaminergic (DA) systems had been previously lesioned by microinjections of 6-hydroxydopamine (6-OHDA). Two groups of VMT neurons innervating each structure could be distinguished. The first group (group S) are slow conducting neurons whose number is reduced in 6-OHDA lesioned rats and which may correspond to A10 DA neurons. The second group (group F) are fast conducting neurons which are resistant to 6-OHDA treatment and therefore probably non-DA VMT cells.

摘要

运用逆向激活法,在正常大鼠以及多巴胺能(DA)系统先前已通过微量注射6-羟基多巴胺(6-OHDA)损毁的动物中,鉴定出位于腹内侧被盖区(VMT)且投射至额叶皮质、隔区或伏隔核的神经元。可区分出两组支配各结构的VMT神经元。第一组(S组)是传导速度慢的神经元,其数量在6-OHDA损毁的大鼠中减少,可能对应于A10 DA神经元。第二组(F组)是传导速度快的神经元,对6-OHDA处理有抗性,因此可能是非DA的VMT细胞。

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