Ohnishi S T, Obzansky D M, Price H L
Can J Physiol Pharmacol. 1980 May;58(5):525-30. doi: 10.1139/y80-086.
(1) Ca2+-binding lipoprotein was purified from dog heart plasma membrane and the effect of several general anesthetics, ethanol, and acetaldehyde on the Ca2+ binding was studied. (2) These drugs, which are known to cause myocardial depression increased the Ca2+ binding at clinically useful concentrations. (3) These results raise the possibility that these drugs, by increasing the Ca2+ binding to the plasma membrane, limit the availability of superficially located Ca2+ for excitation-contraction coupling and result in depression of myocardial contractile force.
(1) 从犬心脏质膜中纯化出钙结合脂蛋白，并研究了几种全身麻醉剂、乙醇和乙醛对钙结合的影响。(2) 已知这些药物会引起心肌抑制，在临床有效浓度下会增加钙结合。(3) 这些结果提示，这些药物可能通过增加钙与质膜的结合，限制表面钙用于兴奋-收缩偶联，从而导致心肌收缩力下降。
