Goss R J
Clin Orthop Relat Res. 1980 Sep(151):270-82.
Reports of fingertip regrowth in children are interpreted in the perspective of epimorphic regeneration in lower forms and in relation to a few other examples in mammals. The latter include cases of antler replacement in deer as well as ingrowth from the margins of holes cut in bat wing membranes and in the external ears of rabbits, pikas, cats, and echolocating bats. It is suggested that the relative inadequacy of regeneration in warm-blooded vertebrates may be attributed to the precocity with which they tend to form dermal scars in healing wounds, scars that are believed to preclude blastema production. Wound healing around the margins of rabbit ear holes is uniquely characterized by the development of prominent epidermal downgrowths adjacent to the severed sheets of dermis in the integument on either side of the ear. If these downgrowths act as epidermal blockades preventing scar formation in favor of allowing blastema cells to accumulate, a logical approach to the experimental induction of regeneration in normally nonregenerating mammalian appendages would involve manipulation of the mechanisms by which epidermis heals amputation stumps.
儿童指尖再生的报道是从低等生物的形态再生角度，并结合哺乳动物的其他一些例子来解读的。后者包括鹿的鹿角替换案例，以及蝙蝠翼膜上的切口边缘向内生长的情况，还有兔子、鼠兔、猫和回声定位蝙蝠的外耳。有人认为，温血脊椎动物再生能力相对不足可能归因于它们在愈合伤口时倾向于过早形成皮肤疤痕，据信这些疤痕会阻止芽基的产生。兔耳孔边缘的伤口愈合具有独特的特征，即耳两侧体被中真皮切断片相邻处会出现明显的表皮向下生长。如果这些向下生长的表皮起到表皮屏障的作用，防止疤痕形成，有利于芽基细胞积累，那么在正常情况下不能再生的哺乳动物附肢中进行再生实验诱导的合理方法，将涉及操纵表皮愈合截肢残端的机制。
