Couture R, Regoli D
Clin Exp Hypertens (1978). 1980;2(1):1-24. doi: 10.3109/10641968009038549.
The effects of angiotensin II (ATII), and noradrenaline (NA) were measured in vivo and in several vascular preparations taken from normotensive intact or from uninephrectomized rats receiving NaCl 0.9% for drinking. The study was directed to evaluate the effects of aging and of uninephrectomy plus NaCl administration on vascular reactivity. Aging neither change the response in vivo or the myotropic effects of the agents in the isolated portal vein, while the effect of ATII was specifically increased in the perfused kidney, and both the response to ATII and NA were decreased in rat hindquarters and thoracic aortae. Uninephrectomy and NaCl administration were accompanied by a selective increase of sensitivity to ATII in vivo and in the isolated kidney, by a stronger effect of both ATII and NA in the hindquarter, while the response of the portal vein did not change and those of the thoracic aorta to ATII and NA showed a tendency to diminish. These results indicate that aging and uninephrectomy have to be taken into account in studies intended to evaluate the sensitivity of vascular preparations of normotensive and hypertensive rats.
在体内以及从正常血压的完整大鼠或接受0.9%氯化钠饮水的单侧肾切除大鼠获取的多种血管制剂中，测量了血管紧张素II（ATII）和去甲肾上腺素（NA）的作用。该研究旨在评估衰老以及单侧肾切除加氯化钠给药对血管反应性的影响。衰老既未改变体内反应，也未改变离体门静脉中这些药物的肌动效应，而在灌注肾中，ATII的效应特异性增强，并且在大鼠后肢和胸主动脉中，对ATII和NA的反应均降低。单侧肾切除和给予氯化钠伴随着体内和离体肾中对ATII敏感性的选择性增加，后肢中ATII和NA的作用更强，而门静脉的反应未改变，胸主动脉对ATII和NA的反应呈降低趋势。这些结果表明，在旨在评估正常血压和高血压大鼠血管制剂敏感性的研究中，必须考虑衰老和单侧肾切除因素。
