Couture R, Rioux F, Regoli D
Clin Exp Hypertens (1978). 1978;1(3):393-405. doi: 10.3109/10641967809068615.
Angiotensin II (AT II), but not noradrenaline (NA) provoked greater pressor effects in anaesthetized rats which have been bilaterally nephrectomized for 24-48 h than in control animals which underwent the same surgical procedure 2-3 h previously. Perfused hindquarters and isolated portal veins derived from bilaterally nephrectomized rats did not exhibit supersensitivity to AT II or NA. Aorta strips removed from rats nephrectomized 48 h before showed a selective decrease of sensitivity to AT II. The results of these in vitro assays suggest that the well known increased pressor effect to AT II, observed in nephrectomized rats cannot be accounted for by an increased sensitivity or large arterial and venous vessels or of the femoral vascular bed.
血管紧张素II（AT II）而非去甲肾上腺素（NA）在双侧肾切除24 - 48小时的麻醉大鼠中引发的升压效应比2 - 3小时前接受相同手术的对照动物更强。来自双侧肾切除大鼠的灌注后肢和分离的门静脉对AT II或NA未表现出超敏反应。48小时前肾切除大鼠的主动脉条对AT II的敏感性选择性降低。这些体外试验结果表明，肾切除大鼠中观察到的对AT II升压效应增加这一众所周知的现象，不能用大动脉、静脉血管或股血管床敏感性增加来解释。
