Crabb G A, Head R J, Hempstead J, Berkowitz B A
Clin Exp Hypertens (1978). 1980;2(1):129-38. doi: 10.3109/10641968009038556.
The levels of norepinephrine (NE), dopamine (DA) and epinephrine (E) in the vasculature of hypertension (DOCA-SALT) and normotensive rats were determined by radioenzymatic assay. Significant decreases in the NE content of the mesenteric artery, renal artery and cardiac tissue from DOCA-Salt treated rats were found. In contrast the NE content of the inferior vena cava, abdominal aorta and mesenteric vein were not significantly decreased in the DOCA-Salt treated rats. There was no evidence of an altered disposition of DA and E in the vasculature of DOCA-Salt treated rats. The results of the study indicate that NE is selectively depleted in the cardiovascular system of this model of experimental hypertension and it is proposed that this property reflects different functional roles of individual elements of the vasculature in the DOCA-Salt hypertensive rat.
通过放射酶法测定了高血压（去氧皮质酮-盐，DOCA-SALT）大鼠和正常血压大鼠血管系统中去甲肾上腺素（NE）、多巴胺（DA）和肾上腺素（E）的水平。发现用DOCA-盐处理的大鼠肠系膜动脉、肾动脉和心脏组织中的NE含量显著降低。相比之下，用DOCA-盐处理的大鼠下腔静脉、腹主动脉和肠系膜静脉中的NE含量没有显著降低。没有证据表明用DOCA-盐处理的大鼠血管系统中DA和E的分布发生改变。研究结果表明，在这种实验性高血压模型的心血管系统中NE被选择性消耗，并且有人提出这种特性反映了DOCA-盐高血压大鼠血管系统中各个组成部分的不同功能作用。
