Goldstein B M, Lai F M, Herzlinger H, Cervoni P
Life Sci. 1982 Oct 11;31(15):1633-8. doi: 10.1016/0024-3205(82)90056-x.
Aorta-coarcted hypertensive rats and sham-operated normotensive rats were compared in order to assess the contribution of sympathetic nervous system activity to the elevated blood pressure in these rats at an early (6 days) and chronic (42 days) stage of hypertension. Norepinephrine (NE), epinephrine (E) and dopamine (DA) levels were quantitated in plasma, heart and vascular tissues (aorta, inferior vena cava, mesenteric artery and vein) using a radioenzymatic procedure. Body weight was significantly reduced and mean arterial blood pressure (MABP) significantly increased in the coarcted rats at both stages of hypertension. Plasma catecholamines did not differ at either stage of hypertension. The NE content of the heart and mesenteric artery was significantly decreased in the coarcted rats at both stages of hypertension but unchanged in the other vessels studied. E and DA levels in the heart and all vasculature analyzed remained unaltered at both stages of hypertension. The present results suggest that neither E nor DA makes a major contribution to the development and maintenance of hypertension in the aorta-coarcted rat. The observation of the reduced cardiac NE concentration in the coarcted rats together with literature reports of similar observations in other animal models of hypertension suggests that myocardial NE depletion is a common feature of the hypertension and not dependent on the methodology used to produce that hypertension.
为了评估交感神经系统活动在主动脉缩窄性高血压大鼠高血压早期（6天）和慢性期（42天）对血压升高的作用，对主动脉缩窄性高血压大鼠和假手术的正常血压大鼠进行了比较。采用放射酶法对血浆、心脏和血管组织（主动脉、下腔静脉、肠系膜动脉和静脉）中的去甲肾上腺素（NE）、肾上腺素（E）和多巴胺（DA）水平进行定量。在高血压的两个阶段，缩窄大鼠的体重显著降低，平均动脉血压（MABP）显著升高。在高血压的任一阶段，血浆儿茶酚胺均无差异。在高血压的两个阶段，缩窄大鼠心脏和肠系膜动脉中的NE含量均显著降低，但在其他研究的血管中未发生变化。在高血压的两个阶段，心脏和所有分析的血管系统中的E和DA水平均保持不变。目前的结果表明，E和DA对主动脉缩窄大鼠高血压的发生和维持均无主要作用。在缩窄大鼠中观察到心脏NE浓度降低，以及在其他高血压动物模型中也有类似观察结果的文献报道，提示心肌NE耗竭是高血压的一个共同特征，且不依赖于产生高血压的方法。
